Astrophysics has been at the forefront of data-intensive research and data science for decades, but the Rubin Observatory Legacy Survey of Space and Time (LSST) is about to usher yet a new era in data-intensive astrophysics. The "next-generation" ground-based astronomical survey, LSST will generate 20TB of information-rich optical-imaging data every night for 10 years starting in 2024 (probably...). The survey is designed to study nearly all subdomains of astrophysics, from the closest Solar System objects to the farthest cosmological explosions, and with a unique data policy that gives unrestricted access to all US and Chilean scientists, it is staged to be truly transformational. I will talk about Rubin's pioneering experiment of community-focused survey design and my role of coordinating a community of 300 time-domain experts and over 2000 scientists overall, and about several time-domain astronomy projects in which members of my UD research group, the FASTLab (Federica's AstroSTatistic Lab), are preparing to discover unusual and even completely new phenomena with LSST. Beyond Rubin, taking pages from what I know to do as an observational astrophysicist, I have expanded the footprint of my research into topics closer to earth, and more directly impactful in our lives: I will discuss, as just two examples, the detection of pollution plumes in urban environments, and recent work of the DEMA COVID-19 Predictive Modeling Group to help the deployment of Delaware hospital resources in the pandemic crises.